Katherine Vorvolakos1, Irada S Isayeva1, Hoan-My Do Luu1, Dinesh V Patwardhan1, Steven K Pollack21Division of Chemistry and Material Science, 2Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USAAbstract: Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices.In all cases, the ability of the HA solution or gel to wet texas rangers pumpkin stencil surfaces and/or disrupt and lubricate interfaces is a limiting feature of its mechanism of action.We synthesized ferric ion–cross-linked galaxy n54 networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis.As cross-linking increases, so do contact angle, viscosity, storage modulus, and loss modulus; thus, wetting and lubrication are compromised.
These findings have implications in medical device materials, such as adhesion barriers and mucosal drug delivery vehicles.Keywords: hyaluron, adhesion barrier, wetting, contact angle, viscosity, lubrication, elasticity, viscoelastic, hydrogel, ferric.